ARGX

argenx SE

Fundamental data last updated:September 6, 2026

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company profile

SECTOR

Healthcare

industry

Biotechnology

Exchange

NASDAQ

County of HQ

NL

Next Earnings Date

Pending Announcement

Business Summary

argenx SE, a biotechnology company established in Amsterdam, the Netherlands, in 2008, is dedicated to developing innovative therapies primarily for autoimmune diseases. The company's operations span across key global markets, including the United States, Japan, Europe, the Middle East, Africa, and China. Its leading investigational therapy is efgartigimod, which is being developed to address a broad range of conditions. These include generalized myasthenia gravis, immune thrombocytopenia, pemphigus vulgaris, chronic inflammatory demyelinating polyneuropathy, thyroid eye disease, bullous pemphigoid, myositis, primary Sjögren's syndrome, post-COVID postural orthostatic tachycardia syndrome, membranous nephropathy, lupus nephropathy, ANCA-associated vasculitis, and antibody-mediated rejection. Also noted in connection with its lead product efforts is ENHANZE SC. The company's extensive development pipeline features several other promising candidates. Empasiprubart is in development for multifocal motor neuropathy, delayed graft function, and dermatomyositis. ARGX-119 is being investigated for congenital myasthenic syndrome and amyotrophic lateral sclerosis. Further pipeline assets include ARGX-213, which targets FcRn; ARGX-121 and ARGX-220, both designed to modulate the immune system; ARGX-109, which targets IL-6; and ARGX-118, developed for inflammatory indications. argenx is also advancing cusatuzumab, ARGX-112, ARGX-114, and ARGX-115. The company’s portfolio encompasses several proprietary products and brands, such as VYVGART, VYVGART HYTRULO, VYVDURA, ARGENX, ABDEG, NHANCE, SIMPLE ANTIBODY, and ARGENXMEDHUB. Strategic collaborations are integral to argenx's business model. It maintains partnerships with AbbVie S.À.R.L., Zai Lab Limited, and LEO Pharma A/S, alongside numerous collaboration and license agreements with entities including Genor Biopharma Co. Ltd, Université Catholique de Louvain, Sopartec S.A., NYU Langone Health, Leiden University Medical Center, AgomAb Therapeutics NV, Broteio Pharma B.V., VIB vzw, University of Texas, BioWa, Inc., and Shire International GmbH. A specific collaboration with Genmab A/S focuses on the discovery, development, and commercialization of novel therapeutic antibodies for immunology and oncology applications. Additionally, argenx has a strategic collaboration with IQVIA Holdings Inc. for the provision of safety systems and related services.

 


VALUATION

P/E

49.88

Market Cap ($M USD)

$56.73B

Forward P/E

15.05

PEG

0.07

PRICE TO SALES

17.00

PRICE TO BOOK

7.78

EV / EBITDA

50.90

5-Year Average P/E

Free Cash Flow Yield

1.29%

DCF Value

$-11311.03

Graham Number

$222.07

Price to FCF

77.29

EV to FCF

72.65

Earnings Yield

1.98%

FCF Yield

1.29%

DIVIDEND

Yield

0.00%

Annual Payout

$0.00

Payout Ratio

0.00%

Consecutive Years of Dividend Growth

5-Year Dividend Growth Rate

Financial Health & Profitability

Earnings Per Share

$18.38

Next Year EPS Growth Estimate

$60.92

Next Year Revenue Growth Estimate

$11.33B

Return on Equity (ROE)

16.82%

FREE CASH FLOW

Operating Margin

25.64%

Debt-to-Equity

0.01

Piotroski F-Score

5

Altman Z-Score

24.37

Return on Invested Capital (ROIC)

11.76%

Current Ratio

5.23

Quick Ratio

4.87

Net Debt to EBITDA

-3.25

Interest Coverage

292.59

Gross Profit margin

89.00%

FCF PER SHARE

$12.09

REVENUE PER SHARE

$55.00

Gainseekers Quantitative Analysis

Summary

The market’s current valuation of ARGX seems to be a tale of two extremes. Despite a Forward P/E of 13.14 suggesting potential undervaluation, the stock trades significantly below its DCF Value, indicating a possible mispricing. The Altman Z-score of 23.33 underscores financial safety, while an Earnings Yield of just 2.32% raises questions about immediate returns. The Graham Number further suggests a disconnect, hinting at a stock priced for growth rather than intrinsic value. Overall, the financial health appears robust, but the valuation narrative is complex.

AI Exposure / Tech Reliance

Operating in the biotechnology sector, ARGX is well-positioned to leverage AI advancements for drug discovery and personalized medicine. The industry's inherent need for innovation aligns with tech shifts, potentially enhancing R&D efficiency. This adaptability could bolster ARGX's competitive edge in a rapidly evolving landscape.

The Bull Case

For the discerning GARP investor, ARGX offers compelling reasons to buy. A robust ROIC of 11.76% indicates efficient capital use, while a Piotroski F-Score of 5 suggests moderate financial strength. The company's impressive operating margin of 25.64% highlights strong pricing power, and a low Debt/Equity ratio of 0.0114 underscores financial prudence. These metrics paint a picture of a company with solid fundamentals and growth potential.

The Bear Case

Despite its strengths, ARGX is not without risks. The Price/Sales ratio of 14.48 and Price/Book of 6.63 suggest a premium valuation, potentially overextended. The EV to EBITDA of 47.11 further highlights this concern, indicating the market's high expectations. Additionally, the stock's proximity to its 52-week high raises caution about technical overextension. Investors should be wary of these valuation pressures.

Market Sentiment & Smart Money

Short Interest %

Analyst Consensus

Buy

Average Analyst Price Target

$1,103.00

Institutional Ownership %

1-Year Beta

-0.02

Insider Buying % (6 Mo)

Distance to 52-Week High

4.01%

Distance to 52-Week Low

41.53%

EARNINGS SURPRISE %

-5.90%

50-DAY SMA

$836.25

200-DAY SMA

$817.75

⚠️ Financial Disclaimer:
This content is for informational purposes only and is not financial advice. Information may be delayed or inaccurate. We may earn a commission from partner links.