AGIO

Agios Pharmaceuticals, Inc.

Fundamental data last updated:June 4, 2026

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company profile

SECTOR

Healthcare

industry

Biotechnology

Exchange

NASDAQ

County of HQ

US

Next Earnings Date

07/30/2026

Business Summary

Agios Pharmaceuticals, Inc., a biopharmaceutical company, engages in the discovery and development of medicines in the field of cellular metabolism and adjacent areas of biology. The company offers PYRUKYND (mitapivat) an activator of both wild-type and a variety of mutant pyruvate kinase, PK, enzymes for the treatment of hemolytic anemias; and AG-946 that is in Phase I clinical study for treating hemolytic anemias and other indications. Agios Pharmaceuticals, Inc. was incorporated in 2007 and is headquartered in Cambridge, Massachusetts.

 


VALUATION

P/E

-4.23

Market Cap ($M USD)

$1.81B

Forward P/E

77.65

PEG

0.74

PRICE TO SALES

27.39

PRICE TO BOOK

1.61

EV / EBITDA

-3.68

5-Year Average P/E

Free Cash Flow Yield

-21.27%

DCF Value

$-27.12

Graham Number

N/A

Price to FCF

-4.70

EV to FCF

-4.50

Earnings Yield

-23.63%

FCF Yield

-21.27%

DIVIDEND

Yield

0.00%

Annual Payout

$0.00

Payout Ratio

0.00%

Consecutive Years of Dividend Growth

5-Year Dividend Growth Rate

Financial Health & Profitability

Earnings Per Share

-$7.19

Next Year EPS Growth Estimate

$0.39

Next Year Revenue Growth Estimate

$68.86B

Return on Equity (ROE)

-34.11%

FREE CASH FLOW

Operating Margin

-719.97%

Debt-to-Equity

0.05

Piotroski F-Score

3

Altman Z-Score

11.96

Return on Invested Capital (ROIC)

-42.23%

Current Ratio

14.19

Quick Ratio

13.59

Net Debt to EBITDA

0.17

Interest Coverage

0.00

Gross Profit margin

82.07%

FCF PER SHARE

$-6.54

REVENUE PER SHARE

$1.12

Gainseekers Quantitative Analysis

Summary

AGIO’s valuation is a paradox wrapped in complexity. The market has priced it with a Forward P/E of 70.89, suggesting high growth expectations, yet its DCF Value is negative, indicating potential overvaluation. The Altman Z-score of 11.81 signals financial safety, but the negative Earnings Yield and ROIC of -42.23% raise red flags about profitability. Despite a robust Current Ratio of 14.19, the stock’s price has been significantly below its 52-week high, hinting at market skepticism. This biotech player is a risky bet, with the market seemingly mispricing its future potential relative to its current fundamentals.

AI Exposure / Tech Reliance

In the rapidly evolving biotech sector, AGIO stands at the forefront of innovation, poised to leverage AI for drug discovery and personalized medicine. The industry's inherent adaptability to tech shifts provides AGIO with a platform to integrate cutting-edge technologies. However, the challenge remains in translating these advancements into sustainable revenue streams.

The Bull Case

For the bullish investor, AGIO presents an intriguing opportunity. Despite its negative FCF Yield and ROIC, the company's low Debt/Equity ratio of 0.052 and a high Gross Profit Margin of 82.07% suggest operational efficiency and pricing power. The Piotroski F-Score of 3 may not scream strength, but the company's ability to maintain a Quick Ratio of 13.59 indicates robust liquidity. These factors, combined with a consensus "Buy" rating, paint a picture of a company with potential upside for those willing to take the risk.

The Bear Case

On the flip side, AGIO's structural weaknesses are glaring. The negative EPS of -$7.19 and an Operating Margin of -719.97% highlight severe profitability issues. Its Price/Sales ratio of 25.02 and Price/Book of 1.47 suggest the stock is expensive relative to its tangible assets and revenue. The negative EV to EBITDA and Price to FCF ratios further underscore cash flow challenges. With a stock price extended above its 50-Day SMA, technical overextension adds another layer of risk.

Market Sentiment & Smart Money

Short Interest %

Analyst Consensus

Buy

Average Analyst Price Target

$42.00

Institutional Ownership %

1-Year Beta

0.58

Insider Buying % (6 Mo)

Distance to 52-Week High

51.22%

Distance to 52-Week Low

26.89%

EARNINGS SURPRISE %

6.63%

50-DAY SMA

$29.50

200-DAY SMA

$32.34

⚠️ Financial Disclaimer:
This content is for informational purposes only and is not financial advice. Information may be delayed or inaccurate. We may earn a commission from partner links.